In this scene, the Florentine Renaissance master, Filippi Lippi, blends the iconography of the Nativity scene with an Adoration of the Christ child by saints. Mary's own posture of adoration is attributed to visions of St. Bridget, written in her "Revelations." Mary is joined by Joseph, Hilarion, Jerome (seen traditionally holding a rock to his chest) and Mary Magdalene. The scene invites reflection on Mary's lived experience of the miraculous, a young woman tasked with the physical care of the Holy Son of God. Jesus' humanity is accented as he lays on the ground unclothed. Simultaneously, Jesus' deity is proclaimed by the angels above who hold a banner with the words "GLORIA IN EXCELSIS DEO."

The painting was originally housed in a convent of San Vincenzo d'Annalena in Florence.